Brand name: methotrexate
Generic name: MTX, Rheumatrex, Methoblastin, amethopterin, Emthexate

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Cutaneous lesions partially remitted following infliximab discontinuation and methotrexate treatment. In patients receiving concomitant methotrexate, the incidence was 6% compared to 26% with Humira monotherapy. Her RA had been treated with methotrexate (10 mg per week) and bucillamine (200 mg per day) for 6 years. Necrotizing fasciitis resulting in death has been reported in a 54-year-old man with rheumatoid arthritis receiving infliximab every 8 weeks along with intramuscular methotrexate weekly dosage. Patients treated with methotrexate should be advised to seek medical attention if they experience potential signs and symptoms of hepatotoxicity such as fever, rash, anorexia, nausea, vomiting, fatigue, right upper quadrant pain, dark urine, and jaundice. Methotrexate has been reported to cause fetal death and/or congenital anomalies. Duration of leucovorin administration varies with the dosage of methotrexate and plasma concentrations achieved (including rate of elimination); in general, leucovorin administration is continued until methotrexate concentrations fall to less than 5 � 10 -8 Molar. MANAGEMENT: The use of methotrexate in combination with other potentially hepatotoxic agents (e. It is recommended that duration of leucovorin administration in these patients be based on determination of plasma methotrexate concentrations.

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